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For many years, perhaps for even several decades, stress has been indicated as a possible cause of hair loss though, to tell the truth, there is no real proof of this. Biological response to stress usually takes place by way of the hypothalamus-hypophisys-surrenal gland axis. There is however another mode involving a large number of interrelated peripheral neurotransmitters and hormones.
These are released by the skin amielinic nerve fibers and they have a direct effect on the way an organism reacts to stress. Psychological or physical stress sets off a chain of molecular reactions by way of the Nerve Growth Factor, the P Substance and Catecholamins. These are all key players which limit hair growth. Some patients who have no family history of Androgenetic Alopecia show widespread hair loss, which is more noticeable in the central area just in the front of the crown, while hair growth continues along the front hairline. A videomicroscope will show a clear depressed erythematosus ring around the infundibula. The root cause of this condition is that the patient is seriously depressed although he/she may not fully be aware of this. However there are marked somatic effects. For these patients, we need to consider a diagnosis of Psychogenetic Alopecia (Daniele Campo's term).
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